Nucleic Acids
Nucleic Acids
By: Victor A. Bloomfield, Donald M. Crothers, Ignacio Tinoco Jr.
This book presents an up-to-date and comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function.
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Title information
Nucleic Acids presents an up-to-date and comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function. With a targeted audience of 1)molecular biologists, 2)physical biochemists, and 3)physical chemists, the book has been carefully organized to reach three different audiences while requiring only introductory physical chemistry and molecular biology as prerequisites. Nucleic Acids will serve as a textbook in physical biochemistry and biophysical chemistry classes, as well as a supplemental text in courses on nucleic acid biochemistry or molecular biology, and as a personal reference for students and researchers in these fields.
1. Introduction
2. Bases, Nucleosides and Nucleotides
3. Chemical and Enzymatic Methods
4. Nucleic Acid Structures from Diffraction Methods
5. Structure and Dynamics by NMR
6. Electronic and Vibrational Spectroscopy
7. Theoretical Methods
8. Conformational Changes
9. Size and Shape of Nucleic Acids in Solution
10. Supercoiled DNA
11. Interaction of Nucleic Acids with Water and Ions
12. Interaction and Reaction with Drugs
13. Protein-Nucleic Acid Interactions
14. Higher Order Structure
Index
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“It was a pleasure to review this book, which is a suitable textbook for graduate courses in physical biochemistry. It provides an update for the widely used text by Cantor and Schimmel…I would recommend this text for graduate classes in physical biochemistry.” “Overall, this is an excellent book that should find use in graduate level biophysical chemistry and physical biochemistry courses and as a reference for physical chemists, physical biochemists, and molecular biologists.” “This work effectively closes a gap in the scientific literature where a comprehensive, updated book has been long overdue. Written by three recognized worldwide experts in the field, the book acts as an up-to-date encyclopedia of nucleic acids with an emphasis on implications for biological functions.” |